AustralieFrV1, Main, Exploration, bibRecord, 005094

Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study

Identifieur interne : 005094 ( Main/Exploration ); précédent : 005093; suivant : 005095

Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study

Auteurs : Helen Kovari [Suisse] ; Caroline A. Sabin [Royaume-Uni] ; Bruno Ledergerber [Suisse] ; Lene Ryom [Danemark] ; Signe W. Worm [Danemark] ; Colette Smith [Royaume-Uni] ; Andrew Phillips [Royaume-Uni] ; Peter Reiss [Pays-Bas] ; Eric Fontas [France] ; Kathy Petoumenos [Australie] ; Stéphane De Wit [Belgique] ; Philippe Morlat [France] ; Jens D. Lundgren [Danemark] ; Rainer Weber [Suisse]

Source :

Clinical infectious diseases [ 1058-4838 ] ; 2013.

RBID : Pascal:13-0134654

Descripteurs français

Pascal (Inist)
- SIDA, Hépatite virale B, Hépatite virale C, Antiviral, Antirétroviral, Foie, Mortalité, Virus hépatite B, Virus hépatite C, Virus immunodéficience humaine, Infection mixte, Effet secondaire, Toxicité, Pronostic.
Wicri :
- topic : Mortalité.

English descriptors

KwdEn :
- AIDS, Antiretroviral agent, Antiviral, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus, Liver, Mixed infection, Mortality, Prognosis, Secondary effect, Toxicity, Viral hepatitis B, Viral hepatitis C.

Abstract

Background. Liver diseases are the leading causes of death in human immunodeficiency virus (HIV)-positive persons since the widespread use of combination antiretroviral treatment (cART). Most of these deaths are due to hepatitis C (HCV) or B (HBV) virus coinfections. Little is known about other causes. Prolonged exposure to some antiretroviral drugs might increase hepatic mortality. Methods. All patients in the Data Collection on Adverse Events of Anti-HIV Drugs study without HCV or HBV coinfection were prospectively followed from date of entry until death or last follow-up. In patients with liver-related death, clinical charts were reviewed using a structured questionnaire. Results. We followed 22 910 participants without hepatitis virus coinfection for 114 478 person-years. There were 12 liver-related deaths (incidence, 0.10/1000 person-years); 7 due to severe alcohol use and 5 due to established ART-related toxicity. The rate of ART-related deaths in treatment-experienced persons was 0.04/1000 person-years (95% confidence interval, .01, .10). Conclusions. We found a low incidence of liver-related deaths in HIV-infected persons without HCV or HBV coinfection. Liver-related mortality because of ART-related toxicity was rare.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<s3>CHE</s3>
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<sZ>14 aut.</sZ>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Antiretroviral agent</term>
<term>Antiviral</term>
<term>Hepatitis B virus</term>
<term>Hepatitis C virus</term>
<term>Human immunodeficiency virus</term>
<term>Liver</term>
<term>Mixed infection</term>
<term>Mortality</term>
<term>Prognosis</term>
<term>Secondary effect</term>
<term>Toxicity</term>
<term>Viral hepatitis B</term>
<term>Viral hepatitis C</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>SIDA</term>
<term>Hépatite virale B</term>
<term>Hépatite virale C</term>
<term>Antiviral</term>
<term>Antirétroviral</term>
<term>Foie</term>
<term>Mortalité</term>
<term>Virus hépatite B</term>
<term>Virus hépatite C</term>
<term>Virus immunodéficience humaine</term>
<term>Infection mixte</term>
<term>Effet secondaire</term>
<term>Toxicité</term>
<term>Pronostic</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Liver diseases are the leading causes of death in human immunodeficiency virus (HIV)-positive persons since the widespread use of combination antiretroviral treatment (cART). Most of these deaths are due to hepatitis C (HCV) or B (HBV) virus coinfections. Little is known about other causes. Prolonged exposure to some antiretroviral drugs might increase hepatic mortality. Methods. All patients in the Data Collection on Adverse Events of Anti-HIV Drugs study without HCV or HBV coinfection were prospectively followed from date of entry until death or last follow-up. In patients with liver-related death, clinical charts were reviewed using a structured questionnaire. Results. We followed 22 910 participants without hepatitis virus coinfection for 114 478 person-years. There were 12 liver-related deaths (incidence, 0.10/1000 person-years); 7 due to severe alcohol use and 5 due to established ART-related toxicity. The rate of ART-related deaths in treatment-experienced persons was 0.04/1000 person-years (95% confidence interval, .01, .10). Conclusions. We found a low incidence of liver-related deaths in HIV-infected persons without HCV or HBV coinfection. Liver-related mortality because of ART-related toxicity was rare.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
</country>
<region><li>Angleterre</li>
<li>Canton de Zurich</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Région de Bruxelles-Capitale</li>
</region>
<settlement><li>Amsterdam</li>
<li>Bruxelles</li>
<li>Londres</li>
<li>Nice</li>
<li>Sydney</li>
<li>Zurich</li>
</settlement>
<orgName><li>Université de Zurich</li>
</orgName>
</list>
<tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Kovari, Helen" sort="Kovari, Helen" uniqKey="Kovari H" first="Helen" last="Kovari">Helen Kovari</name>
</region>
<name sortKey="Ledergerber, Bruno" sort="Ledergerber, Bruno" uniqKey="Ledergerber B" first="Bruno" last="Ledergerber">Bruno Ledergerber</name>
<name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name>
</region>
<name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name>
<name sortKey="Smith, Colette" sort="Smith, Colette" uniqKey="Smith C" first="Colette" last="Smith">Colette Smith</name>
</country>
<country name="Danemark"><noRegion><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
</noRegion>
<name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name>
<name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W." last="Worm">Signe W. Worm</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
</region>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name>
</region>
<name sortKey="Morlat, Philippe" sort="Morlat, Philippe" uniqKey="Morlat P" first="Philippe" last="Morlat">Philippe Morlat</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Petoumenos, Kathy" sort="Petoumenos, Kathy" uniqKey="Petoumenos K" first="Kathy" last="Petoumenos">Kathy Petoumenos</name>
</region>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stéphane" last="De Wit">Stéphane De Wit</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study

Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study

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